Case Studies

Fill Profile Development Lowers Reject Rate for Lyophilized Product

See how smarter filling saved a biologic from a double-digit reject rate. A small amount of liquid left on the vial wall can mean a costly reject, especially when a high-value API is on the line. For one client's high-value biologic, that meant reject rates reaching...

Lyo Cycle Development Ensures Success for Oncology Drug Scale-Up

Find out how engineering-led cycle development bridged the gap from benchtop to validated-scale up. What works on a benchtop doesn't always survive the jump to a large-scale lyophilizer. See how JHS engineers identified the root cause of a failed PPQ validation run...

Increasing Batch Size and Reducing Cycle Times for a Biologic

Challenge An existing partner wanted to work with JHS toinvestigate new ways to reduce the cycle time of abiologic product in order to serve more patients. Approach JHS has worked with this top 20 global pharmapartner for 15+ years on this drug product andsearched for...

AI Predictive Maintenance Prevents Batch Loss and Production Shutdowns

Unplanned equipment failures can lead to costly batch loss and production downtime—especially in biologics manufacturing. In this case study, learn how JHS uses AI-enabled predictive maintenance to stay ahead of risk: Monitor critical equipment like WFI pumps and AHUs...

Case Study: Quadrupling Inspection Speed with Automated Visual Inspection (AVI)

Challenge JHS wanted to maximize the speed and efficiency of the visual inspection process for liquid diluents, a critical part of vaccine manufacturing. Approach After discussions with a key client to better understand our partners’ needs, JHS installed a fully...

Case Study: FTZ Subzone for API Clearance

FTZ Subzone for API Clearance Challenge A customer needed to change from a domestically sourced API (active pharmaceutical ingredient) to an alternative, foreign-made API for a commercial product while avoiding any disruption to patient supply during the switch....